ICEBERG, an inhibitor of pro-caspase-1 activation, consists essentially of only a CARD.
It inhibits generation of IL-1b by interacting with caspase-1 and preventing association with RIP2.
The ICEBERG functions as a competitive antagonist of RIP2/pro-caspase-1 interactions and inhibits caspase-1-dependent pro-L-1b secretion in mononuclear cells.
ICEBERG is induced by proinflammatory stimuli, suggesting that it may be part of a negative feedback loop.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Optimal dilutions to be determined by the researcher.
AA Sequence:MADQLLRKKRRIFIHSVGAGTINALLDCLLEDEVISQEDMNKVRDENDTVMDKARVLIDLVTGKGPKSCCKFIKHLCEEDPQLASKMGLH
Storage and Stability:May be stored at 4℃ for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20℃.
Aliquots are stable for at least 12 months.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ug
抗体種類：Pab
宿主：mouse
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein A affinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.2.
Specificity：Recognizes human ICEBERG.
Isotype：IgG
Calc Applications Abbrev：WB
Calc Crossreactivity：Hu
Immunogen：Full length human ICEBERG, aa1-90 (NP_067546.1).
