83-6002-50　HMG4 (High Mobility Group 4 (HMG) Transcription Factor, High Mobility Group Protein 2a, HMG2a, High Mobility Group Box 3, HMGB3, MGC90319, Nonhistone Chromosomal Protein HMG4) 50ug　127950

特徴

• Hmgb3 belongs to the high mobility group HMG) protein superfamily.
• It contains DNA-binding HMG box domains and is thought to play a fundamental role in DNA replication, nucleosome assembly and transcription.
• Hmgb3 is a sequence-independent chromatin-binding protein that is preferentially expressed in hematopoietic stem cells.
• It can alter DNA structure to facilitate transcription factor binding.
• Enforced expression of Hmgb3 inhibits B-cell and myeloid differentiation and thus, down-regulation of Hmgb3 protein levels has been concluded to be an important step for myeloid and B-cell differentiation.
• Hmgb3 deficiency possibly leads to a failure of hematopoietic stem cells to expand into normal numbers of common lymphoid progenitors and common myeloid progenitors.
• Hmgb3 progenitors attain the ability to expand rapidly and differentiate into normal numbers of hematopoietic cells.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• AA Sequence:MAKGDPKKPKGKMSAYAFFVQTCREEHKKKNPEVPVNFAEFSKKCSERWKTMSGKEKSKFDEMAKADKVRYDREMKDYGPAKGGKKKKDPNAPKRPPSGFFLFCSEFRPKIKSTNPGISIGDVAKKLGEMWNNLNDSEKQPYITKAAKLKEKYEKDVADYKSKGKFDGAKGPAKVARKKVEEEDEEEEEEEEEEEEEEDE
• Storage and Stability:May be stored at 4℃ for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20℃.
• Aliquots are stable for at least 12 months.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.