83-5993-93　CIB1 (Calcium and Integrin-binding Protein 1, CIB, Calcium- and Integrin-binding Protein, CIBP, Calmyrin, DNA-PKcs-interacting Protein, Kinase-interacting Protein, KIP, SNK-interacting Protein 2-28, SIP2-28, CIB, KIP, PRKDCIP) 50ug　124996

特徴

• CIB1 (Calcium and Integrin Binding protein1; also calmyrin, KIP and CIBP) is a 22-23kD, Ca++ binding member of the CIB family of proteins.
• It is widely expressed, being found in neurons, platelets/megakaryocytes, skeletal muscle myocytes and lymphocytes.
• CIB1 is associated with the cytosolic side of the plasma membrane, and has multiple binding partners, including InsP3R, GPIIb aIIb, presenilin 2, and NBR1 plus FEZ.
• When CIB1 binds InsP3R, this ER-embedded receptor is both activated, and later desensitized to subsequent ligand binding.
• Relative to GPIIb, CIB1 interaction with the aIIbB 3 integrin on platelets following thrombin exposure appears to inhibit integrin activation, thus providing a tight control on subsequent platelet binding to fibrinogen.
• Human CIB1 is 191aa in length.
• It contains a utilized myristoylation site at 2aa, followed by two EF-hand domains (aa103-183).
• CIB1 is suggested to act as a monomer.
• There is at least one potential isoform variant that shows a 40aa insertion after 29aa.
• Full length human CIB1 (aa1-191) shares 94% aa sequence identity with mouse CIB1.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• AA Sequence:MGGSGSRLSKELLAEYQDLTFLTKQEILLAHRRFCELLPQEQRSVESSLRAQVPFEQILSLPELKANPFKERICRVFSTSPAKDSLSFEDFLDLLSVFSDTATPDIKSHYAFRIFDFDDDGTLNREDLSRLVNCLTGEGEDTRLSASEMKQLIDNILEESDIDRDGTINLSEFQHVISRSPDFASSFKIVL
• Storage and Stability:May be stored at 4℃ for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20℃.
• Aliquots are stable for at least 12 months.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.