Members of MS4A protein family are characterized by the presence of 4 highly conserved transmembrane domains.
CD20, a 35-37kD Human B-cell specific tetraspan membrane protein, is a unique member of this family.
CD20 plays a major role in the initiation of intracellular signaling and regulating B-cell growth and differentiation.
It complexes with BCR and regulates Calcium ion entry, thereby regulating B-cell signaling and activation.
Antibodies such as Rituximab directed against CD20 are being extensively used for the treatment of B-cell lymphomas.
Applications:Suitable for use in Western Blot, Flow Cytometry and Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Immunohistochemistry (FFPE): 3ug/mlOptimal dilutions to be determined by the researcher.
AA Sequence:MTTPRNSVNGTFPAEPMKGPIAMQSGPKPLFRRMSSLVGPTQSFFMRESKTLGAVQIMNGLFHIALGGLLMIPAGIYAPICVTVWYPLWGGIMYIISGSLLAATEKNSRKCLVKGKMIMNSLSLFAAISGMILSIMDILNIKISHFLKMESLNFIRAHTPYINIYNCEPANPSEKNSPSTQYCYSIQSLFLGILSVMLIFAFFQELVIAGIVENEWKRTCSRPKSNIVLLSAEEKKEQTIEIKEEVVGLTETSSQPKNEEDIEIIPIQEEEEEETETNFPEPPQDQESSPIENDSSP
Storage and Stability:May be stored at 4℃ for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20℃.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ug
抗体種類：Pab
宿主：mouse
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein A affinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.2.
Specificity：Recognizes human MS4A1.
Isotype：IgG
Calc Applications Abbrev：FC IHC WB
Calc Crossreactivity：Hu
Immunogen：Full length protein corresponding to aa1-297 from human MS4A1 (NP_068769.2).
