CD160 is a 27kD member of Ig superfamily of molecules.
It is expressed on select hematopoietic cell types, including CD56dimCD16+ cytotoxic NK cells, CD8+CD28 effector T cells, YdT cells, and restricted CD4+ T cells.
It is a receptor for HLAC molecules, and its engagement induces CD160+ NK cells to both secrete IFN-Y plus TNF-A, and initiate a cytotoxic program.
Human CD160 was originally identified as a 155aa pro-protein aa27-181.
It contains a 132aa mature region aa27-159 and a C-terminal pro-segment that is cleaved to create a GPI linkage.
The mature region possesses one V-type Ig-like domain aa27-122.
CD160 is found as a soluble, disulfide-linked 80kD multimer (likely trimer) that is generated by proteolysis of the GPI-linked form.
This 80kD form, plus others, are highly resistant to reduction.
There is also a 100-110kD multimeric transmembrane (TM) form that is associated with activated NK cells.
It contains a 55aa substitution for aa180-181, and shows a 20aa TM segment between aa163- 182.
The TM form appears to have a splice variant that lacks aa25-133.
Over aa27-159, human CD160 shares only 62% aa sequence identity with mouse CD160.
Applications:Suitable for use in Western Blot.
Other applications not tested.
Recommended Dilution:Optimal dilutions to be determined by the researcher.
