83-5986-62　C7 (Complement Component C7) 50ug　C7850-40E

特徴

• C7, one of the components of the terminal complement complex (TCC), also know as the membrane attack complex (MAC).
• Proteolytic cleavage of C5 by C5 convertase generates C5b which initiates assembly of the C5b-9 MAC.
• This complex is assembled from five precursor molecules in the serum, finalized with the polymerization of C9 which accompanies insertion of the complex into the cell membrane causing cellular lysis.
• C7 occupies an important position in the TCC cascade.
• C7 undergoes a hydrophilic-amphiphilic transition following activation.
• It enables the developing MAC to bind directly to target cell membranes.
• C7 has been shown to exhibit genetic polymorphism.
• Polymorphonuclear leukocytes represent a major source of C7.
• The fact that inflammatory cells have the potential to secrete C7 suggests an important role for locally produced complement in the inflammatory process.
• Applications:Suitable for use in Western Blot.
• Other applications not tested.
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4℃ for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20℃.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.