83-5986-60　CIS-1 (Cytokine-Inducible SH2-containing Protein-1, Suppressor of Cytokine Signalling, SOCS, Protein G18, CISH) 50ug　C5500-03A

特徴

• The protein encoded by this gene contains a SH2 domain and a SOCS box domain.
• The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family.
• CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling.
• The expression of this gene can be induced by IL2, IL3, GM-CSF and EPO in hematopoietic cells.
• Proteasome-mediated degradation of this protein has been shown to be involved in the inactivation of the erythropoietin receptor.
• Multiple transcript variants encoding different isoforms have been found for this gene.
• Applications:Suitable for use in Western Blot and Immunofluorescence.
• Other applications not tested.
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4℃ for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20℃.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.