It is an adaptor protein localized in the nucleus.
It interacts with the Alzheimer's disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein.
APP functions as a cytosolic anchoring site that can prevent the gene product's nuclear translocation.
This encoded protein could play an important role in the pathogenesis of Alzheimer's disease.
It is thought to regulate transcription.
Also it is observed to block cell cycle progression by downregulating thymidylate synthase expression.
Applications:Suitable for use in Western Blot and Immunofluorescence.
Other applications not tested.
Recommended Dilution:Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4℃ for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20℃.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ug
抗体種類：Pab
宿主：mouse
Source Antibody：human
Grade：Purified
Purity：Purified.
Form：Supplied as a liquid in PBS, pH 7.2.
Specificity：Recognizes human APBB1.
Isotype：IgG
Calc Applications Abbrev：IF WB
Calc Crossreactivity：Hu
Immunogen：APBB1 (NP_663722.1, 1-708aa) full-length human protein.
