Cystatin C is a non-glycosilated basic single-chain protein consisting of 120 amino acids with a molecular weight of 13.36kD and is characterized by two disulfide bonds in the carboxy-terminal region.
It belongs to the cystatins superfamilly which inactivates lysosomal cysteine proteinases, e.g.
cathepsin B, H.K, L and S.
Imbalance between Cystatin C and cysteine proteinases is associated with inflammation, renal failure, cancer, Alzheimer's di-sease, multiple sclerosis and hereditary Cystatin C amyloid angiopathy.
Its increased level has been found in patients with autoimune diseases, with colorectal tumors and in patients on dyalisis.
Serum Cystatin C seems to be better marker of glomerular filtration rate than creatinine.
On the other hand, low concentration of Cystatin C presents a risk factor for secondary cardiovascular events.
Applications:Suitable for use in ELISA, Western Blot and Immunohistochemistry.
Other applications not tested.
Recommended Dilutions:Optimal dilutions to be determined by the researcher.
Storage and Stabillty:Lyophilized and reconstituted products are stable for 12 months after receipt at -20℃.
Reconstitute with sterile dH2O.
Aliquot to avoid repeated freezing and thawing.
Store at -20℃.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Further dilutions can be made in assay buffer.
仕様
Size：100ug
抗体種類：Pab
宿主：rat
Source Antibody：rabbit
Grade：Affinity Purified
Purity：Purified by Immunoaffinity chromatography
Form：Supplied as a lyophilized powder from PBS, pH 7.2. No preservative added. Reconstitute with 200ul sterile dH2O. Let the lyophilized pellet dissolve completely.
Specificity：Recognizes rat Cystatin C
Isotype：IgG
Calc Applications Abbrev：E IHC WB
Calc Crossreactivity：Rb Rt
Immunogen：Recombinant protein corresponding to 134aa with an N-Terminal His-Tag from rat Cystatin C expressed in E. coli
