83-5986-26　［取扱停止］SK3, CT (SKCa3, KCNN3, K Ca 2.3, Small Conductance Ca2+-activated Potassium Channel 3, KCNN3, Potassium intermediate/small conductance calcium-activated channel subfamily N member 3) (Not for Export EU) 50ul　S1014-09R

特徴

• KCNN3 forms one of several calcium-activated potassium channels which are activated in a voltage-independent manner and have a relatively small unit conductance and high sensitivity to intracellular calcium.
• Activation is followed by membrane hyperpolarization.
• It is thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization.
• The channel is blocked by apamin.
• KCCN3 contains an intracellular N and C terminus and 6 highly conserved transmembrane segments.
• It exists as a heterooligomer composed of 4 channel subunits each of which binds to a calmodulin subunit which regulates the channel activity through calcium-binding.
• These channels are thought to be potential therapeutic targets for disorders such as sleep apnea or sudden infant death syndrome and for regulating uterine contractions during labor.
• It was also suggested that KCNN3 may contribute to age-dependent decline in learning and memory and synaptic plasticity.
• Also it is thought that KCNN3 channel expression in endothelial cells may be a fundamental determinant of vascular tone and blood pressure.
• Applications:Suitable for use in ELISA and Western Blot.
• Other applications have not been tested.
• Recommended Dilutions:Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4℃ for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20℃.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.