Notch 2 functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination.
Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBP-J kappa and activates genes of the enhancer of split locus.
Notch 2 is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer.
It is expressed in the brain, heart, kidney, lung, skeletal muscle and liver.
Defects in Nothch 2 are the cause of Alagille syndrome type 2 which is a multisystem disorder defined by hepatic bile duct paucity and cholestasis in association with cardiac, skeletal and opthalmologic manifestations.
Applications:Suitable for use in ELISA and Western Blot.
Other applications have not been tested.
Recommended Dilutions:Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4℃ for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20℃.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：50ul
抗体種類：Pab
宿主：mouse
Source Antibody：human
Grade：Serum
Purity：Serum
Form：Supplied as a liquid, 50% glyceol.
Specificity：Reognizes human Notch 2.
Isotype：IgG
Calc Applications Abbrev：E WB
Calc Crossreactivity：Hu
Immunogen：Partial recombinant corresponding to aa26-136 from human Notch 2 with a GST tag.
