83-5985-37　CD227 (MUC-1, Mucin 1, Episialin, MAM-6, CA 15-3, PEM, CD227, EMA) 100ug　052575

特徴

• Mucin-1 (MUC-1), cell surface associated or polymorphic epithelia mucin, is a 500-1000kD proteoglycan expressed by activated T cells, mucosal epithelial cells, and aberrantly expressed on most breast cancers.
• In normal cells, CD227 is heavily glycosylated, whereas in cancerous cells, the glycosylation is incomplete and premature sialation is also observed.
• The protein is anchored to the apical surface of the epithelial cell and functions as a lubricant to keep the cell hydrated and to protect against pathogens.
• It can also function as a signaling molecule by forming a MUC-1/SOS1/GrB2 complex.
• MUC-1 can interact with cancer antigens such as Her2/neu.
• Mucin-1 (MUC-1), cell surface associated or polymorphic epithelia mucin, is a 500-1000kD proteoglycan expressed by activated T cells, mucosal epithelial cells, and aberrantly expressed on most breast cancers.
• In normal cells, CD227 is heavily glycosylated, whereas in cancerous cells, the glycosylation is incomplete and premature sialation is also observed.
• The protein is anchored to the apical surface of the epithelial cell and functions as a lubricant to keep the cell hydrated and to protect against pathogens.
• It can also function as a signaling molecule by forming a MUC-1/SOS1/GrB2 complex.
• MUC-1 can interact with cancer antigens such as Her2/neu.
• Application:Suitable for use in Immunohistochemistry.
• Other applications have not been tested.
• Recommended Dilutions:Immunohistochemistry (formalin-fixed paraffin-embedded): 5-10ug/mlOptimal dilutions to be determined by researcher.
• Storage and Stability:May be stored at 4℃ for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20℃.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.