PTH/Parathyroid hormone is a hormone produced by the parathyroid gland that regulates the concentration of calcium and phosphorus in extracellular fluid.
This hormone elevates blood Ca2+ levels by dissolving the salts in bone and preventing their renal excretion.
It is produced in the parathyroid gland as an 84 amino acid single chain polypeptide.
It can also be secreted as N-terminal truncated fragments or C-terminal fragments after intracellular degradation, as in case of hypercalcemia.
Defects in this gene are a cause of familial isolated hypoparathyroidism (FIH); also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia.
FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone.
Symptoms are seizures, tetany and cramps.
FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism.
Applications:Suitable for use in Immunohistochemistry.
Other applications not tested.
Recommended Dilution:Immunohistochemistry (formalin-fixed paraffin sections): 0.5-1ug/ml for 30 min at RT).
Requires HIER: steam sections in 10mM citrate buffer, pH 6.0, for 10-20 min
Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4℃ for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20℃.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
抗体種類：Mab
宿主：rabbit
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein A affinity chromatography.
Form：Supplied as a liquid in PBS. No preservative added. Also available with BSA and azide, see 590420.
Specificity：Recognizes human parathyroid hormone.
Clone # USB：PTH/1717R (recomb)
Isotype：IgG,k
Calc Applications Abbrev：IHC
Calc Crossreactivity：Hu
Immunogen：Synthetic peptide corresponding to human parathyroid hormone at N-terminal.
