ARAP1 (angiotensin II type 1 receptor-associated protein) is an adaptor protein with ArfGAP and RhoGAP activities, containing five PH domains and ankyrin repeate.
This adaptor seems to serve as a link between phosphoinositide- Arf-, and Rho-mediated cell signaling.
ARAP1 supports the plasma membrane recycling of angiotensin II type 1 receptor (AT1) and is important also for cell-specific trafficking of pro-death receptor TRAIL-R1 (DR4) to the plasma membrane, thus promoting the TRAIL-induced apoptosis in certain cell types.
ARAP1 also affects cell spreading.
Applications:Suitable for use in Immunoprecipitation, Immunocytochemistry and Western Blot.
Other applications not tested.
Recommended Dilution:Western Blot 2ug/mlOptimal dilution to be determined by researcher.
Storage and Stability:May be stored at 4℃ for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20℃.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
抗体種類：Mab
宿主：mouse
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein A affinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 0.09% sodium azide.
Specificity：Recognizes the C-terminal part of human ARAP1 (intracellular epitope).
Clone # USB：ARAP1-2
Isotype：IgG1
Calc Applications Abbrev：IC IP WB
Calc Crossreactivity：Hu
Immunogen：His6-tagged protein corresponding to aa1190-1450 from human ARAP1
