This antigen is present in normal as well as neoplastic plasma cells.
Plasma cells, which are large lymphocytes derived from an antigen-specific B cell, secrete antibodies and are responsible for humoral immunity.
Plasma cells differentiate from B cells upon stimulation by CD4+ lymphocytes.
The B cell acts as an antigen-presenting cell (APC), consuming an offending pathogen, which is taken up by the B cell by phagocytosis and broken down within proteosomes.
Plasma cells contain basophilic cytoplasm; their nucleus contains heterochromatin organized in a characteristic cartwheel arrangement.
052513 superbly recognizes normal and neoplastic plasma cells in routine formalin-fixed, paraffin-embedded tissue sections.
It is of potential value in identifying myeloma or plasmacytoma in bone marrow or other tissues.
It also helps differentiate lympho-plasmacytoid lymphoma from lymphocytic and follicular lymphoma.
Applications:Suitable for use in Immunohistochemistry.
Microwave treatment in 10mM citrate buffer pH 6.0 recommended
Optimal dilutions to be determined by the researcher.
Positive Control:Human tonsil.
Storage and Stability:May be stored at 4℃ for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20℃.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：1mL
抗体種類：Mab
宿主：mouse
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by affinity chromatography.
Form：Supplied as a liquid in PBS, 0.02% sodium azide.
Specificity：Recognizes human Plasma Cell Marker, an intracytoplasmic antigen, which is present in normal as well as neoplastic plasma cells. Does not react with rat. Shows a very high degree of specificity for plasma cells
