Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells.
Has high affinity for folate and folic acid analogs at neutral pH.
Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release.
Required for normal embryonic development and normal cell proliferation (By similarity).
Applications:Suitable for use in Functional Assays.
Other applications not tested.
Recommended Dilution:Optimal dilutions to be determined by the researcher.
Storage and Stability:Store product at 4℃ in the dark.
DO NOT FREEZE! Stable at 4℃ for 12 months after receipt as an undiluted liquid.
Dilute required amount only prior to immediate use.
Further dilutions can be made in assay buffer.
Caution: PE conjugates are sensitive to light.
For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Note: Applications are based on unconjugated antibody.
仕様
Size：100ul
抗体種類：Mab
宿主：human
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein A/G affinity chromatography. ≥95% (SDS-PAGE). Endotoxin: ≤1EU/mg (LAL)
Form：Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).
Specificity：Recognizes human FOLR1. This non-therapeutic antibody uses the same sequence as the therapeutic antibody Mirvetuximab
Isotype：IgG1,k
Calc Crossreactivity：Hu
Immunogen：Recombinant protein corresponding to human FOLR1, expressed in CHO cells.
