BLT1 is a high-affinity G protein-coupled receptor for leukotriene B4 (LTB4) with roles in the pathogenesis of various inflammatory and immune diseases.
It is expressed in most immune cells, including neutrophils, macrophages, eosinophils, and T cells, as well as certain non-immune cells, such as endothelial cells, fibroblasts, and smooth muscle cells.
Binding of LTB4 to BLT1 during the onset of inflammation induces early recruitment and activation of neutrophils and inflammatory polarization of macrophages.
BLT1 activation also mediates effector T cell recruitment, providing a link between innate and adaptive immunity during T cell-mediated inflammation.
Knockdown of Ltbr41, the gene encoding BLT1, improves glucose tolerance and reduces hyperinsulinemia in a mouse model of high-fat diet-induced obesity.
Ltbr41 knockdown prevents joint immune cell infiltration and the development of arthritis in multiple mouse models of osteoarthritis and rheumatoid arthritis.
Loss of Ltbr41 also increases tumor burden and decreases survival in a mouse model of spontaneous colorectal tumor formation.
Applications:Suitable for use in Flow Cytometry.
Other applications not tested.
Recommended Dilutions:Flow Cytometry: 1:100-1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4℃ for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20℃.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
抗体種類：Mab
宿主：mouse
Source Antibody：mouse
Grade：Affinity Purified
Purity：Purified by Protein G affinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.2, 0.02% sodium azide, 50% glycerol.
