Ganglioside GQ1b is a sialic acid-containing glycosphingolipid that has been found in myelin of the oculomotor nerves and dorsal root ganglia, as well as neuromuscular spindle fibers.
It is found on the plasma membrane, where it is anchored by the ceramide moiety with the sialylated oligosaccharide on the extracellular side.
In axonal myelin, it helps to stabilize the paranodal region in the node of Ranvier.
Ganglioside GQ1b is similar in shape to lipo-oligosaccharides (LOS) on the membrane of certain pathogens, including the bacterium C.
jejuni.
Due to this similarity, autoantibodies against ganglioside GQ1b can be formed during infection with C.
jejuni.
Autoantibodies against ganglioside GQ1b are found in the cerebrospinal fluid in a majority of patients during the acute phase of Miller-Fisher syndrome, a rare variant of Guillain-Barré syndrome characterized by eye movement abnormalities, impaired coordination and tendon reflex loss.
Applications:Suitable for use in ELISA, Immunofluorescence and TLC.
Other applications not tested.
Recommended Dilutions:ELISA: 1:500-1:1000Immunofluorescence: 1:10-1:50TLC: 1:500Optional dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4℃ for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20℃.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
抗体種類：Mab
宿主：mouse
Grade：Highly Purified
Purity：Purified by ammonium sulfate precipitation
Form：Supplied as a liquid in PBS, pH 7.2, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes Ganglioside GQ1b. Crossreactivity: Some cross reactivity to GT1a and GD3. Does not react with other gangliosides.
