Fibrinogen is a hexameric glycoprotein that has roles in coagulation and hemostasis.
It is comprised of two sets of Aα, Bβ, and γ polypeptide chains encoded by FGA, FGB, and FGG, respectively, in humans.
Fibrinogen is synthesized in hepatocytes and secreted into the plasma.
Following thrombin-mediated cleavage of N-terminal fibrinopeptides from the Aα and Bβ chains, yielding the α and β chains, respectively, fibrinogen assembles into fibrin protofibrils and then mature fibers, which provide structure and viscoelasticity to blood clots.
Mutations in FGA, FGB, or FGG have been found in patients with afibrinogenemia or hypofibrinogenemia.
Elevated plasma fibrinogen levels are associated with an increased risk of cardiovascular disease.
Fibrinogen can be citrullinated by protein arginine deiminase 2 (PAD2) and PAD4.
Immune complexes containing citrullinated fibrinogen have been found in patients with anti-citrullinated protein antibody-positive rheumatoid arthritis.
Applications:Suitable for use in Western Blot and ELISA.
Other applications not tested.
Recommended Dilutions:Western Blot: 1:1000ELISA: 1:200Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4℃ for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20℃.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
抗体種類：Mab
宿主：mouse
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein G affinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.2, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes citrullinated fibrinogen at 56kD from human samples. Does not react with human Fibrinogen.
