83-5983-30　CD282 (Toll-like Receptor 2, TLR2) (PE) 100Tests　052336-PE

特徴

• Toll like receptors are a family of pattern-recognition receptors involved in the activation and regulation of inflammatory and immune responses activated by invasion of host tissues by microbial pathogens.
• TLR2 plays a role in a range of infections including gram-positive bacteria, mycobacteria, and yeast.
• It is activated by PAMPs, signals to NF-kappa-B which in turn induces cytokine secretion and the inflammatory response.
• This clone was used to characterize the expression of porcine TLR2; cells of the innate immune system - monocytes, macrophages, and granulocytes, but not on peripheral blood lymphocytes were found to express porcine TLR2.
• Swine neutrophils express low levels of TLR2.
• It is also expressed on epithelial cells lining the tracheobronchial and intestinal tracts, bile ducts in the liver and renal tubules, and on the basal layer of the epidermis.
• Applications:Suitable for use in Flow Cytometry.
• Other applications not tested.
• Recommended Dilutions:Flow Cytometry: Neat, 1:2.
• 10ul labels 10e6 cells in 100ulOptimal dilutions to be determined by the researcher.
• Recommended Negative Control:I1904-79D: IgG1 Murine Negative Control (PE)
• Storage and Stability:Store product at 4℃ before and after reconstitution.
• DO NOT FREEZE! Lyophilized and reconstituted products are stable for 12 months after receipt at 4℃.
• Reconstitute lyophilized powder with sterile ddH2O prior to use and store remainder as an undiluted liquid.
• Caution: PE conjugates are sensitive to light.
• For maximum recovery of product centrifuge the original vial prior to removing the cap.