83-5982-45　SV2C 100ug　052240

特徴

• The protein named Synaptic vesicle glycoprotein 2C (SV2C) and encoded by the human name named SV2C/KAA1054 is glycosylated membrane bound protein important in vesicle secretion.
• SV2C is part of the major facilitator superfamily of vesicle movement and fusion proteins and is particularly important is vesicle fusion by maintaining a readily releasable pool of secretory granules.
• Expressed in neural and endocrine cells primarily, SV2C is important for neurotransmission and hormone release.
• SV2C is enriched in small synaptic vesicles and adrenal microsomes but it is not present in chromaffin granules but is found in insulin granules and microvesicles in the pancreas.
• In the brain SV2C, in contrast to SV2A and SV2B, expression is restricted to certain regions.
• High levels of SV2C are found primarily in phylogenetically old brain regions such as the pallidum, the substantia nigra, the midbrain, the brainstem and the olfactory bulb, but SV2C is undetectable in the cerebral cortex and the hippocampus, and found at low levels in the cerebellar cortex.
• Recent research though also demonstrates that SV2C plays an important role in normal operation of the basal ganglia network and SV2C could also be involved in system adaptation during basal ganglia pathology.
• Applications:Suitable for use in Western Blot and Immunohistochemistry.
• Other applications not tested.
• Recommended Dilutions:Immunohistochemistry (paraffin): 1:2000 detected SV2C in human cerebellum and human thalamus tissue
• Western Blot: 0.5ug/ml detected SV2C in 200g of mouse brain tissue lysate
• Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4℃ for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20℃.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.