83-5982-31　IL-9 (Interleukin 9, Cytokine P40) 100ul　052224

特徴

• Interleukin-9 (UniProt: P15248; also known as IL-9, Cytokine P40, T-cell growth factor P40) is encoded by the IL9 gene (Gene ID: 3578) in human.
• IL-9 is a pleiotropic cytokine that plays a significant role in tolerance and inflammation.
• It is expressed by a variety of immune cells.
• It is synthesized with a signal peptide (aa 1-18), which is subsequently cleaved off to generate the mature form.
• It supports the growth of mast cells, T cells, and several other cell types, including erythroid progenitors, fetal thymocytes, human megakaryoblastic leukemic cells, and myeloid precursor cells.
• It is also reported to supports IL-2 independent and IL-4 independent growth of helper T-cells.
• It also plays a role in promoting IgE production by B cells.
• IL-9 actions are mediated via its binding to IL-9R that results in the formation the IL-9R heterocomplex.
• Following its binding to the IL-9R , the SHC is phosphorylated, which then binds to Grb2 that subsequently activates SoS, a GTP exchange factor for Ras GTPases.
• This results in the activation of Ras GTPase that activates Raf kinase followed by the activation of MEK1/2 and ERK1/2.
• Although IL-9 is reported to activate the MAPK pathway in several lymphoid and hematopoietic cells, this activation is weaker compared to other cytokines.
• Elevated levels of IL-9 and IL-9R are observed in lungs of asthmatic subjects.
• Applications:Suitable for use in ELISA, Neutralization, Flow Cytometry and Multiplexing.
• Other applications not tested.
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4℃ for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20℃.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.