83-5982-27　CD261 (TRAIL Receptor 1, TRAIL-R1, Death Receptor 4, DR4, APO2, TNFRSF10A) (FITC) 100ug　052221-FITC

特徴

• TRAIL-R1 (CD261, DR4) is a type I transmembrane protein, also called TRAIL receptor 1.
• The ligand for this DR4 death receptor has been identified and termed TRAIL, which is a member of the TNF family.
• DR4, as many other receptors (Fas, TNFR1, etc.), mediates apoptosis and NF kappaB activation in many cells and tissues.
• Apoptosis, a programmed cell death, is a operating process in normal cellular differentiation and development of multicellular organisms.
• Apoptosis is induced by coupled of certain cytokines (TNF family - TNF, Fas ligand) and their death domain containing receptors (TNFR1, Fas receptor).
• Applications:Suitable for use in Flow Cytometry.
• Other applications not tested.
• Recommended Dilution:Flow Cytometry: 3-5ug/mlOptimal dilutions to be determined by the researcher.
• Excitation Laser:Blue (488nm)
• Storage and Stability:Store product at 4℃ if to be used immediately within two weeks.
• For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20℃.
• Aliquots are stable at -20℃ for 12 months after receipt.
• Dilute required amount only prior to immediate use.
• Further dilutions can be made in assay buffer.
• Caution: FITC conjugates are sensitive to light.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.