Calcitonin Gene Related Peptide [CGRP] is a 37 amino acid peptide and is the most potent endogenous vasodilator currently known (Brain et al.,1985).
CGRP is primarily produced in nervous tissue, however, its receptors are expressed throughout the body.
CGRP is also strongly implicated in the vasodilatory effect of endogenous cannabinoid anandamide in the brain.
This effect was found to be antagonized by capsazepine.
CGRP is also currently a major target of research in regards to factors effecting the onset of migraine headaches (Edvinsson L., 2003).
CGRP antibodies have been used successfully in immunoneutralization (Wong et al., 1993).
Applications:Suitable for use in Immunocytochemistry.
Not suitable for use in Western Blot..
Other applications not tested.
Recommended Dilutions:Immunocytochemistry: 1:50-1:100Optimal dilutions to be determined by the researcher.
Positive Controls:Dorsal root ganglia, pancreas and gut.
Storage and Stability:May be stored at 4℃ for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20℃.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
抗体種類：Mab
宿主：mouse
Source Antibody：rat
Grade：Affinity Purified
Purity：Purified by Protein G affinity chromatography from culture supernatant.
Form：Supplied as a liquid in 10mM HEPES, pH 7.5, 150mM sodium chloride, 0.1mg/mL BSA, 50% glycerol.
Specificity：Recognizes rat CGRP. Species Crossreactivity: human. Also recognizes rat beta-CGRP and human alpha-CGRP (10-fold less sensitivity compared to rat alpha-CGRP).
