CD42a, also known as glycoprotein 9 (GPIX), composes together with GPIb alpha, GPIb beta and GPV the GPIb-IX-V receptor complex critical in the process of platelet-rich thrombus formation by tethering the platelet to a thrombogenic surface.
CD42b binds to von Willebrand factor (VWF) exposed at a site of vascular injury, as well as to thrombin, coagulation factors XI and XII, high molecular wight kininogen, TSP-1, integrin Mac-1 and P-selectin.
Defects in the gene encoding CD42a are a cause of Bernard-Soulier syndrome, also known as giant platelet disease.
These patients have unusually large platelets and have a clinical bleeding tendency.
Applications:Suitable for use in Flow Cytometry.
Other applications not tested.
Recommended Dilution:Flow Cytometry: Use 4ul to label 10e6 cells or 100ul whole blood
Optimal dilutions to be determined by the researcher.
Excitation Laser:Blue (488nm)
Storage and Stability:Store product at 4℃ in the dark.
DO NOT FREEZE! Stable at 4℃ for 12 months after receipt as an undiluted liquid.
Dilute required amount only prior to immediate use.
Further dilutions can be made in assay buffer.
Caution: PE/Cy7 conjugates are sensitive to light.
For maximum recovery of product, centrifuge the original vial prior to removing the cap.
仕様
Size：100Tests
抗体種類：Mab
宿主：mouse
Source Antibody：human
Grade：Highly Purified
Purity：Purified by chromatography
Form：Supplied as a liquid in PBS, pH 7.4, 15mM sodium azide. Labeled with PE/Cy7.
Specificity：Recognizes human CD42a. Species Crossreactivity: canine
