83-5980-76　PCSK9, Alirocumab Biosimilar 1mg　052014

特徴

• Alirocumab biosimilar is a human monoclonal antibody (IgG1 isotype) that targets proprotein convertase subtilisin kexin type 9 (PCSK9), is a PCSK9 inhibitor produced by recombinant DNA technology in Chinese Hamster Ovary cell suspension culture.
• Alirocumab biosimilar consists of two disulfide-linked human heavy chains, each covalently linked through a disulfide bond to a human kappa light chain.
• A single N-linked glycosylation site is located in each heavy chain within the CH2 domain of the Fc constant region of the molecule.
• The variable domains of the heavy and light chains combine to form the PCSK9 binding site within the antibody.
• Alirocumab biosimilar has an approximate molecular weight of 146kD.
• Applications:Suitable for use in Functional Assays.
• Other applications not tested.
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4℃ for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20℃.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.