Cilia- and flagella-associated protein 206 (UniProt: Q6PE87; also known as CFAP206) is encoded by the Cfap206 gene (Gene ID: 69329) in murine species.
CFAP206 is an evolutionarily conserved protein that lacks known motifs or domains, except for a unique 280 amino acid domain with conserved motifs GFC and GIL.
It localizes to the basal body/centrosome and to cilia, and its expression correlates with and depends on Foxj1 expression.
In vertebrates it plays a role during motile cilia assembly, and its deficiency can lead to abnormal ciliary beating and decreased sperm motility.
It is reported to be a potential component of the nexin-dynein regulatory complex and interacts with radial spoke protein 3.
Two isoforms of CFAP206 have been described that are produced by alternative spicing.
Isoform 1 is expressed in the sperm, oviduct, lung, nasal cavity, brain ependyma, and choroid plexus.
This isoform is shown to be essential for sperm motility and is involved in the regulation of the beating frequency of motile cilia on the epithelial cells of the respiratory tract and it is required for the establishment of radial spokes in sperm flagella.
Isoform 2 that is expressed in the sperm, oviduct, lung, nasal cavity, brain ependyma, and choroid plexus is also required for sperm motility and is involved in the regulation of the beating frequency of motile cilia on the epithelial cells of the respiratory tract.
Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4℃ for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20℃.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ul
抗体種類：Mab
宿主：rat
Source Antibody：mouse
Grade：Affinity Purified
Purity：Purified by Protein G affinity chromatography.
Form：Supplied as a liquid in 0.1M Tris-Glycine, pH 7.4, 150mM sodium chloride, 0.05% sodium azide.
Specificity：Recognizes mouse Cilia- and flagella-associated protein 206 (CFAP206), isoform 1. Targets an epitope within 13 amino acids from the C-terminal region, which is missing in isoform 2.
Clone # USB：ORF2-2A7
Isotype：IgG2a,k
Calc Applications Abbrev：WB
Calc Crossreactivity：Mo
Immunogen：Lnear peptide corresponding to 13 amino acids from the C-terminal region of mouse Cilia- and flagella-associated protein 206 (CFAP206).
