83-5979-38　Osteopontin (OPN) 100ug　592476

特徴

• Osteopontin (OPN), also known as bone sialoprotein 1, nephropontin secreted phosphoprotein 1 and uropontin, is an acidic glycoprotein and is a member of the intrinsically disordered class of proteins (Kurzbach et al.
• 2013).
• OPN plays a role in a multitude of physiological and pathophysiological processes.
• In inflammation it induces cell adhesion and migration, regulates differentiation of proinflammatory lymphocytes and inhibits apoptosis of inflammatory cells (Clemente et al.
• 2016).
• OPN is expressed by various cell types including bone, neural, epithelial and endothelial cells.
• It is also expressed by the immune cells T cells, B cells, natural killer cells and macrophages.
• In its secreted form OPN can be found in biological fluids such as blood, urine, bile and milk (Castello et al.
• 2017).
• OPN has been found to play a role in cancer progression by enhancing proliferation, survival, motility and invasion of tumor cells in a range of cancers.
• OPN was upregulated at tumor sites and in blood of the patients, with the level correlating with tumor stage and aggressiveness (Castello et al.
• 2017).
• High levels of OPN have also been detected in several autoimmune diseases including multiple sclerosis and rheumatoid arthritis (Clemente et al.
• 2016).
• Applications:Suitable for use in ELISA.
• Other applications not tested.
• Recommended Dilution:ELISA: 1ug/mlOptimal dilutions to be determined by the researcher.
• Matched Pairs:Capture: 592476Detection: 592477
• Hybridoma:Sp2/0 myeloma cells with spleen cells from Balb/c mice.
• Storage and Stability:May be stored at 4℃ for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20℃.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.