83-5978-68　CXCR5 (C-X-C Chemokine Receptor 5) (APC) 100ug　048679

特徴

• CXCR5 is a 55-60kD member of the G-protein coupled receptor 1 family.
• It is expressed on select cell types, including granule and Purkinje cell neurons, embryonic CD4+ CD3- IL-7Ralpha+ precursor cells, B cells and follicular T helper cells.
• CXCR5 selectively binds BLC/CXCL13.
• This appears to both promote embryonic lymph node development and, in the adult, direct expressing cells to positions that optimize antigen presentation and antibody production.
• Mouse CXCR5 is a 7-transmembrane glycoprotein that is 374 amino acids (aa) in length.
• It contains a 57aa N-terminal extracellular region plus a 47aa C-terminal cytoplasmic domain.
• Over aa1-57, mouse CXCR5 shares 84% and 47% aa identity with rat and human CXCR5, respectively.
• Applications:Suitable for use in Flow Cytometry.
• Other applications not tested.
• Recommended Dilutions:Flow Cytometry: 0.25ug/10e6 cells.
• Detects CXCR5 in mouse splenocytes and T follicular helper cellsOptimal dilutions to be determined by the researcher.
• Storage and Stability:Store product at 4℃ in the dark.
• DO NOT FREEZE! Stable at 4℃ for 12 months after receipt as an undiluted liquid.
• Dilute required amount only prior to immediate use.
• Further dilutions can be made in assay buffer.
• Caution: APC conjugates are sensitive to light.
• For maximum recovery of product, centrifuge the original vial prior to removing the cap.