Ikaros, also known as IKZF1 (Ikaros family zinc finger protein 1) is a hematopoietic-specific transcription factor involved in the regulation of lymphocyte development, together with other members of this family, such as Aiolos and Helios.
Ikaros forms homo- and heterodimers with these proteins and functions predominantly in early hematopoietic development.
Expression of Ikaros, Aiolos and Helios is restricted to cells of the hematopoietic system, whereas other family members, Eos and Pegassus, are more widely expressed.
Disruption of Ikaros leads to T and B cell leukemias.
Applications:Suitable for use in Western Blot, Flow Cytometry, Immunocytochemistry and Immunoprecipitation.
Other applications not tested.
Recommended Dilution:Flow Cytometry: 1-4ug/ml with intracellular staining
Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4℃ for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20℃.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
抗体種類：Mab
宿主：mouse
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein A affinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 15mM sodium azide.
Specificity：Recognizes human Ikaros. Species Crossreactivity: mouse
Clone # USB：4E9
Isotype：IgG1
Calc Applications Abbrev：FC IC IP WB
Calc Crossreactivity：Hu Mo
Immunogen：Recombinant protein corresponding to the C-terminal of human Ikaros
