Helios, also known as IKZF2 (Ikaros family zinc finger protein 2) is a hematopoietic-specific transcription factor involved in the regulation of lymphocyte development, together with other members of this family, such as Aiolos and Ikaros.
Helios forms homo- and heterodimers with these proteins and is thought to function predominantly in early hematopoietic development.
Expression of Helios, Aiolos and Ikaros is restricted to cells of the hematopoietic system, whereas other family members, Eos and Pegassus, are more widely expressed.
Helios is expressed at early stages of thymocyte development.
In mature T cells, Helios has been strongly associated with Treg cells.
Applications:Suitable for use in Flow Cytometry.
Other applications not tested.
Recommended Dilution:Flow Cytometry: 1-4ug/mlOptimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4℃ for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20℃.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
抗体種類：Mab
宿主：hamster
Grade：Affinity Purified
Purity：Purified by Protein A affinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 15mM sodium azide.
Specificity：Recognizes Helios. Species Crossreactivity: mouse and human
Clone # USB：22F6
Isotype：IgG
Calc Applications Abbrev：FC
Calc Crossreactivity：Hu Mo
Immunogen：Peptide coresponding to amino acids 51-107 of Helios
