There are two kinds of IGF receptors based on their relative affinities for IGF1 versus IGF2.
The IGF1 receptor prefers IGF1 over IGF2 and weakly binds insulin.
IGF1 receptor is a disulfide-linked heterotetrameric transmembrane protein consisting of two alpha (130kD) and two beta (95kD) subunits.
Both the alpha and beta subunits are encoded within a single receptor precursor cDNA.
The IGF1 receptor is therefore similar in structure to the insulin receptor.
The proreceptor polypeptide is proteolytically cleaved and disulfide-linked to yield the mature heterotetrameric receptor.
The IGF1 receptor is highly expressed in all cell types and tissues and is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival.
Applications:Suitable for use in Immunoprecipitation and Immunohistochemistry.
Other applications not tested.
Recommended Dilutions:Immunohistochemistry (paraffin): 1:500 detected IGF-1R in human placental villi and tonsil tissue
Optimal dilutions to be determined by the researcher.
Control:Human placental villi and tonsil tissue
Storage and Stability:May be stored at 4℃ for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20℃.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
抗体種類：Mab
宿主：mouse
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein G affinity chromatography.
Form：Supplied as a liquid in 0.1M Tris-Glycine, pH 7.4, 150mM sodium chloride, 0.05% sodium azide.
Specificity：Recognizes human IGF-IR.
Clone # USB：24-57
Isotype：IgG1,k
Calc Applications Abbrev：IHC IP
Calc Crossreactivity：Hu
Immunogen：KLH-conjugated linear peptide corresponding to human IGF-IR.
