83-5978-03　Amyloid Beta, Lecanemab Biosimilar 1mg　047626

特徴

• Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis.
• Interaction between APP molecules on neighboring cells promotes synaptogenesis.
• Involved in cell mobility and transcription regulation through protein-protein interactions.
• Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb.
• Couples to apoptosis- inducing pathways such as those mediated by G(o) and JIP.
• Inhibits G(o) alpha ATPase activity (By similarity).
• Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1 (By similarity).
• By acting as a kinesin I membrane receptor, plays a role in axonal anterograde transport of cargo towards synapses in axons.
• Involved in copper homeostasis/oxidative stress through copper ion reduction.
• In vitro, copper-metallated APP induces neuronal death directly or is potentiated through Cu(2+)-mediated low-density lipoprotein oxidation.
• Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV.
• The splice isoforms that contain the BPTI domain possess protease inhibitor activity.
• Induces a AGER-dependent pathway that involves activation of p38 MAPK, resulting in internalization of amyloid-beta peptide and leading to mitochondrial dysfunction in cultured cortical neurons.
• Provides Cu(2+) ions for GPC1 which are required for release of nitric oxide (NO) and subsequent degradation of the heparan sulfate chains on GPC1.
• N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6).
• Applications:Suitable for use in ELISA, Neutralization, Functional Assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by Lecanemab.
• Other applications not tested.
• Recommended Dilution:Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4℃ for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20℃.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.