83-5977-07　GABA(A) Receptor Subunit Gamma-2 (Gabrg2) 100ul　046259

特徴

• GABA(A) receptor subunit gamma-2 is a protein belonging to a subclass of GABA receptors known as GABA (A).
• GABA (A) receptors are pentameric chloride channels composed of subunits belonging to different homology classes, i.e.
• α, β, γ, δ, θ, ε, π, and act as receptors for GABA, a crucial inhibitory neurotransmitter localized within the brain.
• GABA (A) gamma 2 subunit consists of 5 cysteine residues and carries the binding site for benzodiazepine.
• The subunit functions to promote receptor maintenance and clustering at the synapse, interacts with GABA receptor associated proteins such as GODZ and GABAWRAP, affects GABA (A) receptor conductance and kinetics, and is a contributing component to receptors participating in both phasic and tonic inhibition.
• Several mutations in the GABA(A) receptor subunit gamma-2 expression have been linked to epileptic syndromes that result in fibrile seizures.
• Applications:Suitable for use in Western Blot and Immunocytochemistry.
• Other applications not tested.
• Recommended Dilutions:Western Blot: 1:2000 detected GABA(A) receptor subunit gamma-2 in 10ug of PC-12 cell lysate
• Immunocytochemistry: 1:250 detected GABA(A) receptor subunit gamma-2 in rat hippocampal neurons.
• Optimal dilutions to be determined by the researcher.
• Control:PC-12 cell lysate
• Storage and Stability:May be stored at 4℃ for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20℃.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.