CD178 / Fas-L (Fas ligand, CD95L), a member of TNF family transmembrane glycoproteins, is responsible for induction of apoptosis in cells containing its receptor CD95 / Fas.
The CD178-mediated apoptosis pathway has been implicated in peripheral tolerance, tissue pathology, and maintenance of the immune privileged sites.
Defects in this interaction may be related to some cases of systemic lupus erythematosus (SLE).
CD178 was also described as a co-stimulatory receptor for T-cell activation in mice in vivo.
Applications:Suitable for use in Flow Cytometry, Immunoprecipitation, Western Blot and Immunocytochemistry.
Other applications not tested.
Recommended Dilution:Flow Cytometry: 1-4ug/mlOptimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4℃ for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20℃.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
抗体種類：Mab
宿主：mouse
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein A affinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 15mM sodium azide.
Specificity：Recognizes human CD178,
Clone # USB：NOK-1
Isotype：IgG1
Calc Applications Abbrev：FC IC IP WB
Calc Crossreactivity：Hu
Immunogen：L5178Y mouse T lymphoma cells expressing recombinant human CD178
