83-5976-94　CD354 (TREM-1) (PE) 100Tests　046251-PE

特徴

• CD354 (TREM-1), a cell surface glycoprotein expressed mainly on monocytes, macrophages, and neutrophils, but also on e.g.
• endothelial cells or bronchial epithelium, plays an important role in innate immune responses.
• Upon triggering by its ligands (mainly bacterial and fungal components, but also some viruses, such as Marburg or Ebola virus), it initiates signaling cascades leading to release of pro-inflammatory cytokines and chemokines.
• CD354 is strongly present in infectious inflammatory lesions (e.g.
• in folliculitis or impetigo), but not so much in non-infectious inflammatory lesions, (e.g.
• vasculitis or psoriasis).
• However, under certain conditions neutrophils can upregulate CD354 also under non-infectious inflammatory conditions, e.g.
• in rheumatoid arthritis.
• Soluble CD354 (sTREM-1) is an important biomarker for identification of septic patients, as well as for prediction of their survival.
• Applications:Suitable for use in Flow Cytometry.
• Other applications not tested.
• Recommended Dilution:Flow Cytometry: 10ul labels 10e6 cells in 100ulOptimal dilutions to be determined by the researcher.
• Storage and Stability:Store product at 4℃ in the dark.
• DO NOT FREEZE! Stable at 4℃ for 12 months after receipt as an undiluted liquid.
• Dilute required amount only prior to immediate use.
• Further dilutions can be made in assay buffer.
• Caution: PE conjugates are sensitive to light.
• For maximum recovery of product, centrifuge the original vial prior to removing the cap.