CD354 (TREM-1), a cell surface glycoprotein expressed mainly on monocytes, macrophages, and neutrophils, but also on e.g.
endothelial cells or bronchial epithelium, plays an important role in innate immune responses.
Upon triggering by its ligands (mainly bacterial and fungal components, but also some viruses, such as Marburg or Ebola virus), it initiates signaling cascades leading to release of pro-inflammatory cytokines and chemokines.
CD354 is strongly present in infectious inflammatory lesions (e.g.
in folliculitis or impetigo), but not so much in non-infectious inflammatory lesions, (e.g.
vasculitis or psoriasis).
However, under certain conditions neutrophils can upregulate CD354 also under non-infectious inflammatory conditions, e.g.
in rheumatoid arthritis.
Soluble CD354 (sTREM-1) is an important biomarker for identification of septic patients, as well as for prediction of their survival.
Applications:Suitable for use in ELISA, Flow Cytometry and Western Blot.
Other applications not tested.
Recommended Dilution:Flow Cytometry: 1-4ug/mlOptimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4℃ for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20℃.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
抗体種類：Mab
宿主：mouse
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein A affinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.4, 15mM sodium azide
Specificity：Recognizes human CD354.
Clone # USB：6B1
Isotype：IgG1
Calc Applications Abbrev：E FC WB
Calc Crossreactivity：Hu
Immunogen：Recombinant protein corresponding to human CD354, fused with IgG
