EPO is the major regulator of differentiation, proliferation, and survival of erythroid progenitors.
Hypoxia induces erythropoiesis which causes cells to produce hypoxia inducible factor (HIF) that is directly involved in EPO expression.
HIF-Prolyl hydroxylase (HIF-PH) is a sensor of levels of iron, oxygen, and metabolic activity.
High levels of HIF protein induce EPO production in the kidneys and liver, and mobilize iron to support erythropoiesis.
EPO has been used in the treatment of anemia associated with a number of conditions, such as chronic kidney disease, cancer patients on chemotherapy, and antiviral HIV therapy.
Applications:Suitable for use in Immunoprecipitation.
Other applications not tested.
Recommended Dilution:Immunoprecipitation: 1-5ug/mlOptimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4℃ for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20℃.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
抗体種類：Mab
宿主：mouse
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by affinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Specificity：Recognizes human Erythropoietin.
Clone # USB：M0312E3
Isotype：IgG2b,k
Calc Applications Abbrev：IP
Calc Crossreactivity：Hu
Immunogen：Recombinant protein corresponding to human Erythropoietin.
