Alzheimer’s disease is characterized by the accumulation of aggregated Aβ peptides in senile plaques and vascular deposits.
Aβ peptides are derived from amyloid precursor proteins (APPs) through sequential proteolytic cleavage of APP by β-secretases and γ-secretases generating diverse species of Aβ with differential propensities to fibrillize and deposit in Senile Plaques.
046148 can be used to stain amyloid plaques (diffuse and compact) and amyloid angiopathy on formalin-fixed paraffin-embedded tissue (human AD, Downs syndrome, MCI and transgenic mouse).
Applications:Suitable for use in ELISA and Immunohistochemistry.
Other applications not tested.
Recommended Dilutions:ELISA (detection): 25-50ng/mlImmunohistochemistry (paraffin): 0.5-5ug/mlOptimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4℃ for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20℃.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
抗体種類：Mab
宿主：mouse
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by affinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Specificity：Recognizes Amyloid Beta, aa1-11. Also recognizes full length amyloid precursor protein (APP), soluble APP form (sAPPa), C99 cleavage form, and Aß (1-40 and 1-42). Does not recognize sAPPß.
Clone # USB：NAB 228
Isotype：IgG2a,k
Calc Applications Abbrev：E IHC
Calc Crossreactivity：Hu
Immunogen：Peptide sequence corresponding to amino acids 1-11 of human amyloid beta (Aβ) protein.
