83-5975-51　CD137 (4-1BB) (APC) 100Tests　046131

特徴

• CD137, also known as TNFRSF9 or 4-1BB, is an inducible costimulatory molecule expressed mainly on activated T cells.
• Its ligand, known as 4-1BBL, is expressed on activated macrophages, mature B cells, hematopoietic stem cells, and myeloid progenitor cells.
• CD137 signaling leads to maintaining the survival of activated T cells and CD8+ memory T cells, and clonal expansion of T cells, but also to suppressing myelopoiesis and dendritic cell development.
• Triggered CD137 induces a cytokine release profile regulating peripheral monocyte survival.
• Soluble forms of CD137 may provide negative control mechanism for some immune responses.
• Applications:Suitable for use in Flow Cytometry.
• Other applications not tested.
• Recommended Dilution:Flow Cytometry: 10ul labels 10e6 cells in 100ul
• Optimal dilutions to be determined by the researcher.
• Storage and Stability:Store product at 4℃ in the dark.
• DO NOT FREEZE! Stable at 4℃ for 12 months after receipt as an undiluted liquid.
• Dilute required amount only prior to immediate use.
• Further dilutions can be made in assay buffer.
• Caution: APC conjugates are sensitive to light.
• For maximum recovery of product, centrifuge the original vial prior to removing the cap.