HVEM, a member of the TNFR superfamily, is a type I transmembrane protein containing 2 TNF receptor domains with a predicted molecular weight of approximately 30kD.
HVEM is widely expressed in blood vessels, brain, heart, kidney, liver, lung, prostate, spleen, thymus and other organs.
Resting T cells and naïve and memory B cells express high levels of HVEM as well.
In humans, HVEM is not expressed in germinal center B cells.
Immature dendritic cells express high levels of HVEM that is downregulated upon maturation.
HVEM plays an important role in herpes simplex virus pathogenesis by enhancing entry into cells.
Signaling through HVEM activates JNK1, NF-kB and AP-1 to control gene expression in response to infection or cellular stress and activate the immune response.
HVEM binds to LIGHT and has also been shown to associate with several other proteins including TRAF1, TRAF2, TRAF3, TRAF5, B and T lymphocyte associated protein (BTLA), and estrogen receptor alpha.
Applications:Suitable for use in Flow Cytometry.
Other aplications not tested.
Recommended Dilutions:Flow Cytometry: 5ul labels 10e6 cells in 100ulOptimal dilution to be determined by the researcher.
Storage and Stability:Store product at 4℃ in the dark.
DO NOT FREEZE! Stable at 4℃ for 12 months after receipt as an undiluted liquid.
Dilute required amount only prior to immediate use.
Further dilutions can be made in assay buffer.
Caution: APC conjugates are sensitive to light.
For maximum recovery of product, centrifuge the original vial prior to removing the cap.
仕様
Size：100Tests
抗体種類：Mab
宿主：mouse
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by affinity chromatography.
Form：Supplied as a liquid in PBS, pH 7.2, BSA, 0.09% sodium azide. Labeled with Allophycocyanin (APC).
Specificity：Recognizes human TR2 (HVEM, Herpes Virus Entry Mediator).
Clone # USB：122
Isotype：IgG1,k
Calc Applications Abbrev：FC
Calc Crossreactivity：Hu
Immunogen：Recombinant human HVEM protein. Species sequence homology: African Green, Baboon, Cynomolgus, Rhesus
