83-5974-83　CD206 (Mannose Receptor, Macrophage Mannose Receptor, Macrophage Mannose Receptor 1, MMR, Mannose Receptor C Type 1, MRC1) (APC) 100ug　045958

特徴

• CD206, also known as mannose receptor (MR), is a 175 kD type I membrane protein.
• It is a pattern recognition receptor (PRR) belonging to the C-type lectin superfamily.
• MR is expressed on macrophages, dendritic cells, Langerhans cells, and hepatic or lymphatic endothelial cells.
• MR recognizes a range of microbial carbohydrates bearing mannose, fucose, or N-acetyl glucosamine through its C-type lectin-like carbohydrate recognition domains, sulfated carbohydrate antigens through its cysteine-rich domain, and collagens through its fibronectin type II domain.
• MR mediates endocytosis and phagocytosis as well as activation of macrophages and antigen presentation.
• It plays an important role in host defense and provides a link between innate and adaptive immunity.
• Recently, MR on lymphatic endothelial cells was found to be involved in leukocyte trafficking and a contributor to the metastatic behavior of cancer cells.
• It suggests that MR may be a potential target in controlling inflammation and cancer metastasis by targeting the lymphatic vasculature.
• Applications:Suitable for use in Flow Cytometry.
• Other applications not tested.
• Recommended Dilution:Flow Cytometry (intracellular immunofluorescent staining): ≤0.5ug labels 10e6 cells in 100ulOptimal dilutions to be determined by the researcher.
• Storage and Stability:Store product at 4℃ in the dark.
• DO NOT FREEZE! Stable at 4℃ for 12 months after receipt as an undiluted liquid.
• Dilute required amount only prior to immediate use.
• Further dilutions can be made in assay buffer.
• Caution: APC conjugates are sensitive to light.
• For maximum recovery of product, centrifuge the original vial prior to removing the cap.