83-5974-46　RhoG (ARHG, RHOG Ras Homolog Gene Family, Member G (Rho G)) 100ug　045918

特徴

• RhoG (ARGH) is a member of the Ras super-family of small G-proteins and a member of the Rac subfamily of Rho Family of GTPases.
• RhoG is a small G-protein (GTPase) who is activated by a GEF (guanine nucleotide exchange factor).
• The GEF displaces GDP from the binding site of RhoG and allows GTP to bind in it place rendering the protein active.
• This active RhoG binds downstream effector molecules that include ELMO and DOCK180.
• RhoG then cleaves GTP to GDP making it inactive.
• RhoG is believed to be crucial for integrin-mediated Rac activation and cell spreading.
• RhoG is believed to be active upstream of Rac and work independently of Rac.
• Applications:Suitable for use in IWestern Blot.
• Other applications have not been tested.
• Recommended Dilution:Optimal dilution determined by the researcher.
• Storage and Stability:May be stored at 4℃ for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20℃.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.