83-5974-41　PAR-1 (Proteinase-Activated Receptor 1, F2R, CF2R, PAR1, TR) 100ug　045913

特徴

• The protein named Proteinase-activated receptor 2 (PAR2/PAR-2), or Coagulation factor II receptor-like 1, G-protein coupled receptor 11, Thrombin receptor-like-1 and encoded by the human gene F2RL1/GPR11/PAR2 is a receptor for trypsin and trypsin-like enzymes coupled to G proteins.
• Its function is mediated through the activation of several signaling pathways including phospholipase C (PLC), intracellular calcium, mitogen-activated protein kinase (MAPK), I-kappaB kinase/NF-kappaB and Rho.
• Also as part of the innate and adaptive immunity response, PAR2 acts as sensor for proteolytic enzymes generated during infection and works to promote inflammation and the inflammatory response.
• PAR2 is also involved in vascular and airway tone and in blood pressure regulation and many other G protein coupled receptor response pathways.
• PAR2 is a multi-pass membrane protein that is widely expressed in most tissues except brain or skeletal muscle.
• Applications:Suitable for use in Western Blot, Flow Cytometry, Immunocytochemistry and Immunofluorescence.
• Other applications not tested.
• Recommended Dilutions:Western Blot: 1ug/ml detected Par-1 in 10ug of mouse lymph node tissue
• Flow Cytometry: 4ug detected Par-1 in 10e6 human thrombocytes (platelets)
• Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4℃ for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20℃.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.