Humanized IgG1 kappa isotype monoclonal antibody that binds to human CD11a.
Efalizumab has a molecular weight of ~150kD and is produced in a Chinese hamster ovary mammalian cell expression system in a nutrient medium containing the antibiotic gentamicin.
Efalizumab binds to CD11a, a subunit of leukocyte function antigen-1 (LFA-1), which is expressed on all leukocytes.
As a result efalizumab decreases cell surface expression of CD11a.
Efalizumab Biosimilar uses the same protein sequences as the therapeutic antibody efalizumab.
Efalizumab is a monoclonal anti-CD11a antibody used to treat moderate to severe plaque psoriasis.
Applications:Suitable for use in ELISA, Neutralization, Functional Assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by Efalizumab.
Other applications not tested.
Recommended Dilution:Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4℃ for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20℃.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
