83-5974-01　LAMP1 (Lysosome-associated Membrane Glycoprotein 1, LAMP-1, Lysosome-associated Membrane Protein 1, CD107 Antigen-like Family Member A, CD107a) (APC) 100Tests　L9190-10N-APC

特徴

• CD107a, also known as Lysosome-Associated Membrane Protein 1 (LAMP-1) or LGP-120, is a 110-140kD type I membrane glycoprotein.
• The mature CD107a is heavily glycosylated from a 40kD core protein.
• It is expressed by activated platelets, activated lymphocytes, macrophages, epithelial cells, endothelial cells, and some tumor cells.
• This molecule is located on the luminal side of lysosomes and has been suggested to play a role in the protection of lysosome membrane from lysosomal hydrolases.
• Upon activation, CD107a is transferred to the cell membrane surface.
• It plays a role in cell adhesion and regulation of tumor metastasis, and mediates autoimmune disease progression.
• CD107a is a ligand for galaptin and E-selectin.
• Applications:Suitable for use in Flow Cytometry.
• Other applications not tested.
• Recommended Dilutions:Flow Cytometry: 5ul/10e6 cells in 100ul volume or 100ul whole bloodOptimal dilutions to be determined by the researcher.
• Storage and Stability:Store product at 4℃ in the dark.
• DO NOT FREEZE! Stable at 4℃ for 12 months after receipt as an undiluted liquid.
• Dilute required amount only prior to immediate use.
• Further dilutions can be made in assay buffer.
• Caution: APC conjugates are sensitive to light.
• For maximum recovery of product, centrifuge the original vial prior to removing the cap.