83-5973-92　Integrin alpha V beta 6 100ug　045863

特徴

• Integrins are heterodimeric transmembrane receptors comprising alpha and beta subunits that function as cell anchoring and signaling molecules.
• The ITGAV gene encodes integrin alpha V, a type I integral membrane glycoprotein known as the vitronectin receptor α chain, or CD51.
• It forms a heterodimer with integrin β1 (CD29), β3 (CD61), β5, β6, or β8.
• Integrin αV contains two disulfide-linked subunits of 125 kD and 24 kD, and is expressed on endothelial cells, fibroblasts, macrophages, platelets, osteoclasts, neuroblastoma, melanoma, and hepatoma cells.
• Integrin beta 6 is a protein that in humans is encoded by the ITGB6 gene.
• The β6 subunit only combines with αV to generate a single heterodimer.
• Integrin αVβ6 is a subtype of the integrin family expressed exclusively on epithelial cells.
• Integrin αVβ6 is usually expressed at low or undetectable levels in normal adult tissues but can be highly upregulated during pathological and physiological processes such as wound healing, fibrosis, inflammation, and cancer.
• Applications:Suitable for use in Flow Cytometry.
• Other potential applications in references, though not tested, include Immunoprecipitation and Immunocytochemistry.
• Other applications not tested.
• Recommended Dilutions:Flow Cytometry: ≤0.25ug/10e6 in 100ul Optimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4℃ for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20℃.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.