IL-38 (IL-1F10) belongs to the IL-1 family of proteins.
IL-38 is expressed in heart, placenta, fetal liver, spleen, thymus and tonsil.
The expression in a variety of immune tissues and similarity to IL-1Ra suggest a role of IL-38 as a IL-1 family receptor antagonist.
Il-38 inhibits IL-36 signaling by binding to IL-1R6.
IL-38 (aa 20-152) is released from apoptotic cells to limit inflammatory macrophage and downstream Th17 activation by blocking IL1RAPL1 (Interleukin-1 receptor accessory protein-like 1, TIGIRR-2) signaling.
IL-38 is unregulated during some autoimmune diseases such as Systemic Lupus Erythematosus.
Applications:Suitable for use in ELISA, Western Blot and Immunocytochemistry.
Other applications not tested.
Recommended Dilutions:Western Blot: 1:1000Immunocytochemistry: 1:500ELISA: 1:2000Optimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4℃ for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20℃.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
抗体種類：Mab
宿主：mouse
Source Antibody：human
Grade：Affinity Purified
Purity：Purified by Protein A affinity chromatography from hybridoma tissue culture supernatant. ≥95% (SDS-PAGE)
Form：Supplied as a liquid in PBS, 0.02% sodium azide, 10% glycerol.
Specificity：Recognizes human IL-38. Species Crossreactivity: mouse
