83-5973-61　HDAC1 (Histone Deacetylase 1) [KO Validated] 100ul　045817

特徴

• HDAC1 (histone deacetylase 1) is a 65kD member of the Class I histone deacetylase family, which is similar to the yeast RPD3 protein.
• This nuclear protein operates in concert with histone acetyltransferases to control core histone acetylation in highly conserved lysine residues.
• HDAC activity has been associated with transcriptional repression and nucleosomal condensation.
• HDAC1 deacetylates RELA at residue K310, which results in the inhibition of NF-kB activity.
• HDAC1 has been suggested to participate in the regulation of eukaryotic gene expression and cell cycle progression.
• HDAC1-deficient mice were shown to be embryonic lethal, suggesting that HDAC1 plays a crucial role during embryonic development.
• Applications:Suitable for use in Western Blot and Immunohistochemistry.
• Other applications not tested.
• Recommended Dilutions:Immunohistochemistry (paraffin): 10ug/mlWestern Blot: 5-10ug/mlOptimal dilutions to be determined by the researcher.
• Storage and Stability:May be stored at 4℃ for short-term only.
• Aliquot to avoid repeated freezing and thawing.
• Store at -20℃.
• Aliquots are stable for 12 months after receipt.
• For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.