8-Hydroxy-2'-deoxyguanosine (8-OH-dG) and 8-hydroxyguanosine (8-OHG) are oxidized nucleosides and markers of DNA and RNA oxidative damage, respectively.
Levels of 8-OH-dG increase in DNA in the presence of eugenol and hydrogen peroxide or copper sulfate.
Levels of 8-OHG increase in response to hydrogen peroxide in HeLa cells in a concentration-dependent manner.
8-OHG has been detected in neurons in postmortem brain from patients with Alzheimer's or Parkinson's disease.
Applications:Suitable for use in ELISA and Immunoprecipitation.
Other applications not tested.
Recommended Dilutions:ELISA: 1:1000Immunoprecipitation: 10ug/reactionOptimal dilutions to be determined by the researcher.
Storage and Stability:May be stored at 4℃ for short-term only.
Aliquot to avoid repeated freezing and thawing.
Store at -20℃.
Aliquots are stable for 12 months after receipt.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
仕様
Size：100ug
抗体種類：Mab
宿主：mouse
Grade：Highly Purified
Purity：Purified by ammonium sulfate precipitation.
Form：Supplied as a liquid in PBS, pH 7.2, 0.1% BSA, 0.02% sodium azide, 50% glycerol.
Specificity：Recognizes 8-hydroxy-2-deoxyguanosine and 8-hydroxy Guanosine.
